The Center of Translational Genomics (CTG) established in 2011, is focused on the development of an unique and universal database based on the Estonian Biobank, where genetic variation, genome transcription and epigenetic alterations are described in detail (association analysis, gene expression profiling, eQTL mapping, linear modeling, DNA methylation analysis etc.), together with the characterization of full proteomes (content, modifications and concentrations) and metabolomes (final products of metabolism) as a direct result of the previous processes.
This database to be developed within 5 years period (2011-2015) will include different biological data of randomly selected participants who have joined the Estonian Biobank previously. All workgroups at the University of Tartu involved in the CTG include top-level team leaders, with specific knowledge and infrastructure, aimed at making a joint effort to add basic scientific knowledge into the advancement of personalized medicine.
Our vision is a world where an understanding of genetic variation, genome transcription and epigenetic alterations together with the characterization of full proteomes and metabolomes can be rapidly translated to the diagnosis and treatment of different diseases at the level of individual patients.